BIOL 3011: Genetics (Gotesman): Unit 3: Mendelian Heredity in Humans

Lecture 5: Review trihybrid cross, Chi Square, Chromosome validation, sex-linked traits, introduction of pedigree analysis

Lecture 6: Rules for pedigree analysis, Chromosomal Aneuploidy

Expected Outcomes – you should…

1. Demonstrate understanding of the different inheritance patterns of autosomal linked genes and sex-chromosome linked genes
2. Demonstrate understanding of the importance of chromosome balance and X-chromosome inactivation
3. Demonstrate understanding of the relationship between meiosis and primary and secondary nondisjunction
4. Demonstrate understanding of when pedigrees are consistent or inconsistent with different modes of inheritance (autosomal vs sex- chromosome linked; recessive vs dominant)
5. Demonstrate understanding of how pedigree analysis is useful in the physical mapping of genes
6. Demonstrate understanding of how pedigrees are made