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BIOL 3011: Genetics (Gotesman): Unit 3: Mendelian Heredity in Humans

Genetics: BIOL 3011

Topics for Unit 3: Mendelian Heredity in Humans

Lecture 5: Review trihybrid cross, Chi Square, Chromosome validation, sex-linked traits, introduction of pedigree analysis

Lecture 6: Rules for pedigree analysis, Chromosomal Aneuploidy

Expected Outcomes – you should…

  1. Demonstrate understanding of the different inheritance patterns of autosomal linked genes and sex-chromosome linked genes
  2. Demonstrate understanding of the importance of chromosome balance and X-chromosome inactivation
  3. Demonstrate understanding of the relationship between meiosis and primary and secondary nondisjunction
  4. Demonstrate understanding of when pedigrees are consistent or inconsistent with different modes of inheritance (autosomal vs sex- chromosome linked; recessive vs dominant)
  5. Demonstrate understanding of how pedigree analysis is useful in the physical mapping of genes
  6. Demonstrate understanding of how pedigrees are made

Readings: X-linked genes

Videos: Sex Chromosome Linkage


Attribution:
[Useful Genetics] (2014, Jan. 28) Lecture 7E - Detecting sex-linkage, predicting outcomes [Video File]. Retrieved from https://youtu.be/mk1X52grkOc

Attribution:
[Useful Genetics] (2014, Jan. 22) Lecture 4A - Sex chromosomes and sex determination [Video File]. Retrieved from https://youtu.be/NYc_ksSpcUE

Attribution:
[Useful Genetics] (2014, Jan. 27) Lecture 6J - Sex chromosomes in meiosis [Video File]. Retrieved from https://youtu.be/SWpZSVRkTUo

Attribution:
[Useful Genetics] (2014, Jan. 28) Lecture 4B - Expression of X‐linked genes in females [Video File]. Retrieved fromhttps://youtu.be/un6x2fHrC10

Attribution:
[Useful Genetics] (2014, Jan. 22) Lecture 4C - Expression of X‐linked genes in males [Video File]. Retrieved from https://youtu.be/FJOK99qau-E

Attribution:
[Angelika Amon] (2013, Feb. 27) Angelika Amon (MIT and HHMI) Part 1: Review of the Study of Aneuploidy [Video File]. Retrieved from https://youtu.be/0XF4D9cCJOA

Attribution:
[Useful Genetics] (2014, Jan. 31) Lecture 9C - Aneuploidy for sex chromosomes [Video File]. Retrieved from https://youtu.be/2yAJrSeaIJo

Attribution:
[Useful Genetics] (2014, Jan. 31) Lecture 9B - Aneuploidy [Video File]. Retrieved from https://youtu.be/HG94fHCTUtY

Readings: Pedigree Analysis

Videos: Pedigree Analysis


Attribution:
[East Tennessee State University] (2017, Sept. 13) Cytogenetics II Chromosome Analysis & Karyotypes [Video File]. Retrieved from https://youtu.be/X9tRGdlA_20

Attribution:
[Shomu's Biology] (2013, Dec. 8) Pedigree analysis- autosomal dominant [Video File]. Retrieved from https://youtu.be/ixClJFVN2Vk

Attribution:
[Biologybyme] (2013, Dec. 8) Pedigree Flowchart [Video File]. Retrieved from https://youtu.be/z0cwhooDZ0M

Attribution:
[Biologybyme] (2013, Dec. 8) X Linked Recessive Pedigree [Video File]. Retrieved from https://youtu.be/BFIw1jWv9_s

Attribution:
[Biologybyme] (2013, Dec. 8) Autosomal Recessive Pedigree [Video File]. Retrieved from https://youtu.be/yd5BEEbgkTU

Attribution:
[Biologybyme] (2013, Dec. 8) X Linked Dominant Pedigree [Video File]. Retrieved from https://youtu.be/-JIBcv3VMA0